KMID : 1161420220250080828
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Journal of Medicinal Food 2022 Volume.25 No. 8 p.828 ~ p.835
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Beneficial Effects of Fructooligosaccharides Esterified with Lauric Acid in a Metabolic Syndrome Model Induced by a High-Fat and High-Carbohydrate Diet in Wistar Rats
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Hernandez-Perez Susana
Oliart-Ros Rosa Maria Casas-Godoy Leticia Sandoval Georgina Guarner-Lans Veronica Castrejon-Tellez Vicente Quevedo-Corona Lucia Pena-Montes Carolina Ramirez-Higuera Abril
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Abstract
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Metabolic syndrome (MS) is a group of abnormalities in which obesity, insulin resistance (IR), oxidative stress, and dyslipidemia stand out. This pathology predisposes to the development of cardiovascular diseases and diabetes. The ingestion of linear fructooligosaccharides (FOS) such as inulin reduces conditions such as hyperinsulinemia, increased body fat, and triglyceridemia. When FOS are esterified with fatty acids, they present emulsifying and surfactant properties; however, there are no reports of their function at the biological level. The purpose of this investigation was to evaluate the effect of Agave tequilana Weber's FOS (AtW-FOS) and FOS esterified with lauric acid (FOS-LA) in MS markers in a rat model induced by a HFHC diet. Supplementation with AtW-FOS and FOS-LA decreased IR, improved glucose tolerance, reduced liver weight (19%), plasma triglycerides (24%), and blood pressure (16%) when compared with the untreated MS group. In conclusion, the ingestion of AtW-FOS and FOS-LA has beneficial effects in the prevention of MS alterations, showing a high potential for their application in functional foods.
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KEYWORD
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Agave, fructooligosaccharides, high-fat high-carbohydrate diet, lauric acid, prebiotics
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