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KMID : 1161420220250080828
Journal of Medicinal Food
2022 Volume.25 No. 8 p.828 ~ p.835
Beneficial Effects of Fructooligosaccharides Esterified with Lauric Acid in a Metabolic Syndrome Model Induced by a High-Fat and High-Carbohydrate Diet in Wistar Rats
Hernandez-Perez Susana

Oliart-Ros Rosa Maria
Casas-Godoy Leticia
Sandoval Georgina
Guarner-Lans Veronica
Castrejon-Tellez Vicente
Quevedo-Corona Lucia
Pena-Montes Carolina
Ramirez-Higuera Abril
Abstract
Metabolic syndrome (MS) is a group of abnormalities in which obesity, insulin resistance (IR), oxidative stress, and dyslipidemia stand out. This pathology predisposes to the development of cardiovascular diseases and diabetes. The ingestion of linear fructooligosaccharides (FOS) such as inulin reduces conditions such as hyperinsulinemia, increased body fat, and triglyceridemia. When FOS are esterified with fatty acids, they present emulsifying and surfactant properties; however, there are no reports of their function at the biological level. The purpose of this investigation was to evaluate the effect of Agave tequilana Weber's FOS (AtW-FOS) and FOS esterified with lauric acid (FOS-LA) in MS markers in a rat model induced by a HFHC diet. Supplementation with AtW-FOS and FOS-LA decreased IR, improved glucose tolerance, reduced liver weight (19%), plasma triglycerides (24%), and blood pressure (16%) when compared with the untreated MS group. In conclusion, the ingestion of AtW-FOS and FOS-LA has beneficial effects in the prevention of MS alterations, showing a high potential for their application in functional foods.
KEYWORD
Agave, fructooligosaccharides, high-fat high-carbohydrate diet, lauric acid, prebiotics
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